SELECTIVE CYTOTOXIC CYCLOLIGNANS

被引：28

作者：

GORDALIZA, M ^{[1
]}

DELCORRAL, JMM ^{[1
]}

CASTRO, MA ^{[1
]}

LOPEZVAZQUEZ, ML ^{[1
]}

GARCIA, PA ^{[1
]}

SANFELICIANO, A ^{[1
]}

GARCIAGRAVALOS, MD ^{[1
]}

机构：

[1] PHARMAMAR SA, E-28760 MADRID, SPAIN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 21期

关键词：

D O I：

10.1016/0960-894X(95)00432-S

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several derivatives of podophyllotoxin, lacking the lactone moiety and with nitrogen substituents at C-7 or C-9, have been prepared. They have been evaluated for their cytotoxic activity in P-388, A-549, HT-29 and MEL-28 culture cells. Some of them show a highly selective cytotoxicity towards HT-29 human colon carcinoma.

引用

页码：2465 / 2468

页数：4

共 8 条

[1]

AYRES DC, 1990, CHEM BIOL CLIN PROPE, pCH3

[2] CONFORMATIONAL-ANALYSIS OF PODOPHYLLOTOXIN AND ITS CONGENERS - STRUCTURE-ACTIVITY RELATIONSHIP IN MICROTUBULE ASSEMBLY [J].