AN EXTENDED PANEL OF HAMSTER-HUMAN HYBRIDS FOR CHROMOSOME 2Q

被引：4

作者：

HAFEZPARAST, M

COLE, CG

KAUR, GP

ATHWAL, RS

JEGGO, PA

机构：

[1] SANGER CTR,CAMBRIDGE CB10 1RQ,ENGLAND

[2] TEMPLE UNIV,SCH MED,FELS INST CANC RES & MOLEC BIOL,PHILADELPHIA,PA 19140

来源：

SOMATIC CELL AND MOLECULAR GENETICS | 1994年 / 20卷 / 06期

关键词：

D O I：

10.1007/BF02255844

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A hamster-human hybrid containing only the q arm of chromosome 2 has been used to construct a panel of hybrids bearing reduced regions of chromosome 2 using the technique of irradiation fusion gene transfer. The human chromosome 2 carried the Ecogpt gene and all hybrids were selected using this marker. The integrated Ecogpt gene was localized to the region 2q33-34, resulting in the selective retention of this region in the hybrids. These data were combined with another previously constructed panel of hybrids containing regions of 2q, which were enriched for the region 2q36-37. The combined hybrid panel is useful for the mapping of new markers to defined regions of chromosome 2 and for the cloning of genes located on 2q by a positional strategy.

引用

页码：541 / 548

页数：8

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