THE SYNTHESIS OF NATURALLY-OCCURRING (-)-CALYCULIN-A

被引：61

作者：

TANIMOTO, N ^{[1
]}

GERRITZ, SW ^{[1
]}

SAWABE, A ^{[1
]}

NODA, T ^{[1
]}

FILLA, SA ^{[1
]}

MASAMUNE, S ^{[1
]}

机构：

[1] MIT,DEPT CHEM,CAMBRIDGE,MA 02139

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1994年 / 33卷 / 06期

关键词：

D O I：

10.1002/anie.199406731

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several intriguing transformations culminated in the first total synthesis of the title compound 1—the nonnatural ent‐1 had been published previously—on coupling the fragments A, A′, B, and C. Crucial steps of the synthesis are the aldol reactions in the construction of fragment B, which solved the tricky problem of the stereoselective coupling of chiral fragments. (Figure Presented.) Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：673 / 675

页数：3

共 25 条

[21] USE OF 2-TRIMETHYLSILYLETHYL AS A PROTECTING GROUP IN PHOSPHATE MONOESTER SYNTHESIS
SAWABE, A
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[22] CALYCULIN SYNTHETIC STUDIES - STEREOSELECTIVE CONSTRUCTION OF THE C(14)-C(25) SPIROKETAL SUBUNIT
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[23] STEREOSPECIFIC CROSS-COUPLING OF VINYL HALIDES WITH VINYL TIN REAGENTS CATALYZED BY PALLADIUM
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[24] STRUCTURALLY DIFFERENT MEMBERS OF THE OKADAIC ACID CLASS SELECTIVELY INHIBIT PROTEIN SERINE THREONINE BUT NOT TYROSINE PHOSPHATASE-ACTIVITY
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[J]. TOXICON, 1992, 30 (08) : 873 - 878
[25] TOWARDS THE SYNTHESIS OF CALYCULIN - A SYNTHETIC INTERMEDIATE CORRESPONDING TO THE C(26)-C(37) FRAGMENT
VACCARO, HA
LEVY, DE
SAWABE, A
JAETSCH, T
MASAMUNE, S
[J]. TETRAHEDRON LETTERS, 1992, 33 (15) : 1937 - 1940

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