REDUCTION OF THE HEMOLYTIC EFFECT IN A BIOLOGICALLY RECOGNIZABLE BETA-CYCLODEXTRIN

被引：11

作者：

LERAY, E

LEROYLECHAT, F

PARROTLOPEZ, H

DUCHENE, D

机构：

[1] BIOCIS,CYCLODEXTRINES AMPHIPHILES GRP,CNRS,URA 1843,VILLEURBANNE,FRANCE

[2] LAB PHYSICOCHIM PHARMACOTECH & BIOPHARM,CNRS,URA 1218,VILLEURBANNE,FRANCE

[3] UNIV LYON 1,F-69622 VILLEURBANNE,FRANCE

[4] UNIV PARIS 11,CTR PHARM,F-92296 CHATENAY MALABRY,FRANCE

来源：

SUPRAMOLECULAR CHEMISTRY | 1995年 / 5卷 / 02期

关键词：

D O I：

10.1080/10610279508029487

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

beta-cyclodextrin derivatives having azido, amino and bioactive galactosylamido spacer functions were tested for haemolytic effect and compared with that of hydroxypropyl-beta-cyclodextrin. The cyclodextrin coupled to the bioactive saccharide galactose via a spacer and which has bio-recognition properties for cell-wall lectin shows an extremely reduced haemolytic effect.

引用

页码：149 / 151

页数：3

共 18 条

[11] AN APPROACH TO VECTORIZATION OF PHARMACOLOGICALLY ACTIVE MOLECULES - THE COVALENT BINDING OF LEU-ENKEPHALIN TO A MODIFIED BETA-CYCLODEXTRIN [J].