DIRECT PREPARATION OF GUANIDINE FROM TRICHLOROACETAMIDE - A POTENTIALLY IMPORTANT METHOD TO (-)-TETRODOTOXIN

被引：53

作者：

YAMAMOTO, N ^{[1
]}

ISOBE, M ^{[1
]}

机构：

[1] NAGOYA UNIV, SCH AGR SCI, ORGAN CHEM LAB, NAGOYA, AICHI 464, JAPAN

来源：

CHEMISTRY LETTERS | 1994年 / 12期

关键词：

D O I：

10.1246/cl.1994.2299

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Trichloroacetamides obtained via Overman [3,3] sigmatropic rearrangement were converted into dibenzyl guanidines. The key step was conversion of carbodiimide intermediate into guanidine by scandium or ytterbium trifluoromethane-sulfonates. This method was applied to a synthesis of guanidinium ring of (-)-tetrodotoxin.

引用

页码：2299 / 2302

页数：4

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