DETECTION OF NEW 7-0-ACYL DERIVATIVES OF DIARRHETIC SHELLFISH POISONING TOXINS BY LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY

被引：102

作者：

MARR, JC ^{[1
]}

HU, T ^{[1
]}

PLEASANCE, S ^{[1
]}

QUILLIAM, MA ^{[1
]}

WRIGHT, JLC ^{[1
]}

机构：

[1] NATL RES COUNCIL CANADA,ATLANTIC REG LAB,INST MARINE BIOSCI,HALIFAX B3H 3Z1,NS,CANADA

来源：

TOXICON | 1992年 / 30卷 / 12期

关键词：

D O I：

10.1016/0041-0101(92)90034-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A novel method for the detection of acylated diarrhetic shellfish poisoning toxins is reported. Direct determination of these compounds is possible using high performance liquid chromatography coupled with ion-spray mass spectrometry. An extract, purified from the digestive glands of toxic mussels (Mytilus edulis) contaminated with okadaic acid, dinophysistoxin-1, and a recently reported analog, dinophysistoxin-2, was also shown to contain small amounts of dinophysistoxin-3, a mixture of 7-O-acyl ester derivatives of dinophysistoxin-1. In addition, acyl ester derivatives of okadaic acid and dinophysistoxin-2 were also detected by direct LC-MS analysis and confirmed by analysis of their hydrolysis products. This is the first report of the detection of other naturally occurring 7-O-acyl esters similar to dinophysistoxin-3.

引用

页码：1621 / 1630

页数：10

共 14 条

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