GENETIC DEFICIENCIES OF COMPLEMENT

被引：7

作者：

LOKKI, ML ^{[1
]}

COLTEN, HR ^{[1
]}

机构：

[1] WASHINGTON UNIV, SCH MED, EDWARD MALLINCKRODT DEPT PEDIAT, ST LOUIS, MO 63110 USA

来源：

ANNALS OF MEDICINE | 1995年 / 27卷 / 04期

关键词：

COMPLEMENT; DEFICIENCY; GENETIC DEFECT; CLINICAL MANIFESTATION; INFECTION; RHEUMATOLOGIC DISEASE; ANGIODEMA;

D O I：

10.3109/07853899509002453

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genetic deficiencies of proteins of the complement system are associated with diverse clinical phenotypes. The clinical manifestations vary as a function of the specific component that is missing. Molecular and cellular biological methods, coupled with more intensive clinical studies, have defined the pathophysiological basis for this set of genetic disorders. Insights into the normal function of complement and its role in immunopathology have been derived from the extensive work in this field during the past few years.

引用

页码：451 / 459

页数：9

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