PHOSPHATIDYLCHOLINE-PHOSPHOLIPASE-C MEDIATES THE INDUCTION OF NERVE GROWTH-FACTOR IN CULTURED GLIAL-CELLS

被引：16

作者：

LAVIADA, ID ^{[1
]}

BAUDET, C ^{[1
]}

GALVEROPERH, I ^{[1
]}

NAVEILHAN, P ^{[1
]}

BRACHET, P ^{[1
]}

机构：

[1] CHRU,INSERM,U298,F-49100 ANGERS,FRANCE

来源：

FEBS LETTERS | 1995年 / 364卷 / 03期

关键词：

NERVE GROWTH FACTOR; PHOSPHATIDYLCHOLINE; PROTEIN KINASE C; SPHINGOSINE; GLIAL CELL; ASTROCYTE;

D O I：

10.1016/0014-5793(95)00414-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Addition of phosphatidylcholine-hydrolyzing phospholipase C (PC-PLC) to cultured glial cells increased the levels of nerve growth factor (NGF) mRNA and the amount of cell-secreted NGF, The effect of PC-PLC was 2.5 times higher than that elicited by 4 beta-phorbol 12 beta-myristate 13 alpha-acetate. In cells in which protein kinase C (PKC) was fully inhibited or downregulated, the effect of PC-PLC was reduced - though still evident - and similar to that exerted by sphingosine. Results thus indicate that PC-PLC induces the synthesis of NGF by glial cells by a PKC-dependent and PKC-independent mechanisms.

引用

页码：301 / 304

页数：4

共 27 条

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