NEW CHIRAL BETA-PHOSPHINOCARBOXYLIC ACIDS AND THEIR APPLICATION IN PALLADIUM-CATALYZED ASYMMETRIC ALLYLIC ALKYLATIONS

被引：101

作者：

KNUHL, G ^{[1
]}

SENNHENN, P ^{[1
]}

HELMCHEN, G ^{[1
]}

机构：

[1] UNIV HEIDELBERG,INST ORGAN CHEM,D-69120 HEIDELBERG,GERMANY

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 18期

关键词：

D O I：

10.1039/c39950001845

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chiral beta-phosphinocarboxylic acids conveniently available by conjugate addition of lithium diarylphosphides to alpha,beta-unsaturated carboxylic esters from the chiral pool, show excellent potential as ligands in asymmetric catalysis; in Pd-catalysed allylic substitutions extremely high enantiomeric excess (up to >99% e.e.) is achieved with cyclic substrates.

引用

页码：1845 / 1846

页数：2

共 12 条

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