BRAIN ENZYME IS THE TARGET OF DRUG TOXIN

被引：31

作者：

LEWIN, R

机构：

来源：

SCIENCE | 1984年 / 225卷 / 4669期

关键词：

D O I：

10.1126/science.6433484

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：1460 / 1462

页数：3

共 12 条

[1] A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].

BURNS, RS ;

CHIUEH, CC ;

MARKEY, SP ;

EBERT, MH ;

JACOBOWITZ, DM ;

KOPIN, IJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14) :4546-4550

[2] METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE [J].

CHIBA, K ;

TREVOR, A ;

CASTAGNOLI, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) :574-578

[3] DOPAMINERGIC NEUROTOXICITY OF 1-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE IN MICE [J].

HEIKKILA, RE ;

HESS, A ;

DUVOISIN, RC .

SCIENCE, 1984, 224 (4656) :1451-1453

[4] PARKINSONISM-INDUCING NEUROTOXIN, N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE - CHARACTERIZATION AND LOCALIZATION OF RECEPTOR-BINDING SITES IN RAT AND HUMAN-BRAIN [J].

JAVITCH, JA ;

UHL, GR ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (14) :4591-4595

[5] MONKEY MODEL OF PARKINSONS-DISEASE [J].

KOLATA, G .

SCIENCE, 1983, 220 (4598) :705-705

[6] CHRONIC PARKINSONISM IN HUMANS DUE TO A PRODUCT OF MEPERIDINE-ANALOG SYNTHESIS [J].

LANGSTON, JW ;

BALLARD, P ;

TETRUD, JW ;

IRWIN, I .

SCIENCE, 1983, 219 (4587) :979-980

[7] PARGYLINE PREVENTS MPTP-INDUCED PARKINSONISM IN PRIMATES [J].

LANGSTON, JW ;

IRWIN, I ;

LANGSTON, EB ;

FORNO, LS .

SCIENCE, 1984, 225 (4669) :1480-1482

[8] 1-METHYL-4-PHENYLPYRIDINIUM ION (MPP+) - IDENTIFICATION OF A METABOLITE OF MPTP, A TOXIN SELECTIVE TO THE SUBSTANTIA NIGRA [J].

LANGSTON, JW ;

IRWIN, I ;

LANGSTON, EB ;

FORNO, LS .

NEUROSCIENCE LETTERS, 1984, 48 (01) :87-92

[9] TRAIL OF IRONIES TO PARKINSONS-DISEASE [J].

LEWIN, R .

SCIENCE, 1984, 224 (4653) :1083-1085

[10] 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE DESTROYS DOPAMINE NEURONS IN EXPLANTS OF RAT EMBRYO MESENCEPHALON [J].

MYTILINEOU, C ;

COHEN, G .

SCIENCE, 1984, 225 (4661) :529-531

← 1 2 →