SYNTHESIS OF ARTIFICIAL HMG-COA REDUCTASE INHIBITORS BASED ON THE OLEFINATION STRATEGY

被引：33

作者：

HIYAMA, T ^{[1
]}

MINAMI, T ^{[1
]}

TAKAHASHI, K ^{[1
]}

机构：

[1] TOKYO INST TECHNOL, RESOURCES UTILIZAT RES LAB, MIDORI KU, YOKOHAMA, KANAGAWA 226, JAPAN

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1995年 / 68卷 / 01期

关键词：

D O I：

10.1246/bcsj.68.364

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthetic methods were studied for optically active 6-oxo-3,5-isopropylidenedioxyhexanoate esters (4), which could be used as a key precursor of various kinds of artificial analogs of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. An enantiomer (+)-4 was prepared by asymmetric reduction of beta,delta-diketo esters derived from the Taber's alcohol or L-tartrate followed by a series of chemical transformations, and the desired enantiomer (-)-4 was prepared by the same asymmetric reduction starting from D-tartrate. The key intermediate (-)-4 was finally converted into a highly potent HMG-CoA reductase inhibitor, NK-104.

引用

页码：364 / 372

页数：9

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