THE ROLE OF HYDROGEN-BONDING IN DRUG RECEPTOR INTERACTIONS

被引：25

作者：

HADZI, D ^{[1
]}

KIDRIC, J ^{[1
]}

KOLLER, J ^{[1
]}

MAVRI, J ^{[1
]}

机构：

[1] PHARMACEUT & CHEM WORKS, LJUBLJANA, YUGOSLAVIA

来源：

JOURNAL OF MOLECULAR STRUCTURE | 1990年 / 237卷

关键词：

D O I：

10.1016/0022-2860(90)80136-8

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Amongst the usual components of free energy of interaction between molecules, particular hydrogen bonds may be crucial for the specificity of interaction. Without information on the receptor structure, it is, however, difficult to single out the role of hydrogen bonding from that of other components. This problem will be illustrated by examples of various drugs and corroborated by energy analysis of a simple computational model of receptor-drug interaction. The model permits conjecture about a possible receptor triggering mechanism involving proton transfer. © 1990.

引用

页码：139 / 150

页数：12

共 34 条

[31] A FREE-ENERGY PERTURBATION STUDY OF THE BINDING OF METHOTREXATE TO MUTANTS OF DIHYDROFOLATE-REDUCTASE [J].