Exercise training as S-Klotho protein stimulator in sedentary healthy adults: Rationale, design, and methodology

被引:69
作者
Amaro-Gahete, Francisco J. [1 ,2 ]
De-la-O, Alejandro [1 ]
Jurado-Fasoli, Lucas [1 ]
Espuch-Oliver, Andrea [3 ]
Robles-Gonzalez, Lidia [1 ]
Navarro-Lomas, Gines [1 ]
de Haro, Tomas [4 ]
Femia, Pedro [5 ]
Castillo, Manuel J. [1 ]
Gutierrez, Angel [1 ]
机构
[1] Univ Granada, Sch Med, Dept Med Physiol, Granada, Spain
[2] Univ Granada, PROmoting FITness & Hlth Phys Act Res Grp PROFITH, Dept Phys Educ & Sports, Fac Sport Sci, Granada, Spain
[3] HU Virgen de Las Nieves, Complejo Hosp Granada, Unidad Gest Clin Lab Clin, Granada 18016, Spain
[4] HU San Cecilio, Complejo Hosp Granada, Unidad Gest Clin Lab Clin, Granada 18016, Spain
[5] Univ Granada, Fac Med, Dept Stat, Granada, Spain
关键词
D O I
10.1016/j.conctc.2018.05.013
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 [基础医学];
摘要
Aims: The secreted form of the a-Klotho gene (S-Klotho), which is considered a powerful biomarker of longevity, makes it an attractive target as an anti-ageing therapy against functional decline, sarcopenic obesity, metabolic and cardiovascular diseases, osteoporosis, and neurodegenerative disorders. The S-Klotho plasma levels could be related to physical exercise inasmuch physical exercise is involved in physiological pathways that regulate the S-Klotho plasma levels. FIT-AGEING will determine the effect of different training modalities on the S-Klotho plasma levels (primary outcome) in sedentary healthy adults. FIT-AGEING will also investigate the physiological consequences of activating the klotho gene (secondary outcomes). Methods: FIT-AGEING will recruit 80 sedentary, healthy adults (50% women) aged 45-65 years old. Eligible participants will be randomly assigned to a non-exercise group, i.e. the control group, (n = 20), a physical activity recommendation from World Health Organization group (n = 20), a high intensity interval training group (n = 20), and a whole-body electromyostimulation group (n = 20). The laboratory measurements will be taken at the baseline and 12 weeks later including the S-Klotho plasma levels, physical fitness (cardiorespiratory fitness, muscular strength), body composition, basal metabolic rate, heart rate variability, maximal fat oxidation, health blood biomarkers, free-living physical activity, sleep habits, reaction time, cognitive variables, and health-related questionnaires. We will also obtain dietary habits data and cardiovascular disease risk factors.
引用
收藏
页码:10 / 19
页数:10
相关论文
共 88 条
[1]
Determination of the exercise intensity that elicits maximal fat oxidation [J].
Achten, J ;
Gleeson, M ;
Jeukendrup, AE .
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2002, 34 (01) :92-97
[2]
Connecting obesity, aging and diabetes [J].
Ahima, Rexford S. .
NATURE MEDICINE, 2009, 15 (09) :996-997
[3]
Effects of whole-body vibration and resistance training on knee extensors muscular performance [J].
Artero, E. G. ;
Espada-Fuentes, J. C. ;
Argueelles-Cienfuegos, J. ;
Roman, A. ;
Gomez-Lopez, P. J. ;
Gutierrez, A. .
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 2012, 112 (04) :1371-1378
[4]
BALKE B, 1959, U S Armed Forces Med J, V10, P675
[5]
A comparison between three rating scales for perceived exertion and two different work tests [J].
Borg, E ;
Kaijser, L .
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, 2006, 16 (01) :57-69
[6]
PSYCHOPHYSICAL BASES OF PERCEIVED EXERTION [J].
BORG, GAV .
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 1982, 14 (05) :377-381
[7]
Bright P., 2016, NEUROPSYCHOL REHABIL, V1, P1
[8]
High-Intensity Interval Training, Solutions to the Programming Puzzle Part I: Cardiopulmonary Emphasis [J].
Buchheit, Martin ;
Laursen, Paul B. .
SPORTS MEDICINE, 2013, 43 (05) :313-338
[9]
Exercise Promotes Healthy Aging of Skeletal Muscle [J].
Cartee, Gregory D. ;
Hepple, Russell T. ;
Bamman, Marcas M. ;
Zierath, Juleen R. .
CELL METABOLISM, 2016, 23 (06) :1034-1047
[10]
Anti-aging therapy through fitness enhancement [J].
Castillo-Garzon, Manuel J. ;
Ruiz, Jonatan R. ;
Ortega, Francisco B. ;
Gutierrez, Angel .
CLINICAL INTERVENTIONS IN AGING, 2006, 1 (03) :213-220