EXPERIMENTAL AUTOIMMUNE UVEORETINITIS - A MODEL SYSTEM FOR IMMUNOINTERVENTION - A REVIEW

被引:68
作者
FORRESTER, JV [1 ]
LIVERSIDGE, J [1 ]
DUA, HS [1 ]
DICK, A [1 ]
HARPER, F [1 ]
MCMENAMIN, PG [1 ]
机构
[1] UNIV WESTERN AUSTRALIA,DEPT ANAT & HUMAN BIOL,NEDLANDS,WA 6009,AUSTRALIA
基金
英国惠康基金;
关键词
D O I
10.3109/02713689208999509
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Experimental autoimmune uveoretinitis (EAU) is a useful model of human posterior uveitis and as such, permits the analysis of strategies for immuno-intervention. Modulation of the autoimmune response may be attempted at the stages of induction of EAU, during homing of autoreactive lymphocytes to the target organ, the retina, or during the effector stage of the disease. This paper presents a brief overview of current immuno-therapeutic modalities and assesses the usefulness for extrapolation to human disease.
引用
收藏
页码:33 / 40
页数:8
相关论文
共 38 条
[1]  
ATALLA L, 1990, INVEST OPHTH VIS SCI, V31, P7
[2]  
CANELLA B, 1991, LAB INVEST, V65, P23
[3]  
COHEN IR, 1988, SCI AM, V258, P34
[4]  
CROSS AH, 1990, LAB INVEST, V63, P162
[5]   PREVENTION OF EXPERIMENTAL AUTOIMMUNE UVEORETINITIS BY ACTIVE IMMUNIZATION WITH AUTOANTIGEN-SPECIFIC MONOCLONAL-ANTIBODIES [J].
DEKOZAK, Y ;
MIRSHAHI, M ;
BOUCHEIX, C ;
FAURE, JP .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1987, 17 (04) :541-547
[6]  
DIKJSTRA CD, 1985, IMMUNOLOGY, V54, P589
[7]   S-ANTIGEN - CHARACTERIZATION OF A PATHOGENIC EPITOPE WHICH MEDIATES EXPERIMENTAL AUTOIMMUNE UVEITIS AND PINEALITIS IN LEWIS RATS [J].
DONOSO, LA ;
MERRYMAN, CF ;
SERY, TW ;
SHINOHARA, T ;
DIETZSCHOLD, B ;
SMITH, A ;
KALSOW, CM .
CURRENT EYE RESEARCH, 1987, 6 (09) :1151-1159
[8]   IMMUNOMODULATION OF EXPERIMENTAL AUTOIMMUNE UVEITIS USING A RAT ANTI RETINAL S-ANTIGEN SPECIFIC MONOCLONAL-ANTIBODY - EVIDENCE FOR A SPECIES-DIFFERENCE [J].
DUA, HS ;
LIVERSIDGE, J ;
FORRESTER, JV .
EYE, 1989, 3 :69-78
[9]   ULTRASTRUCTURAL PATHOLOGY OF THE BARRIER SITES IN EXPERIMENTAL AUTOIMMUNE UVEITIS AND EXPERIMENTAL AUTOIMMUNE PINEALITIS [J].
DUA, HS ;
MCKINNON, A ;
MCMENAMIN, PG ;
FORRESTER, JV .
BRITISH JOURNAL OF OPHTHALMOLOGY, 1991, 75 (07) :391-397
[10]   STRUCTURE-FUNCTION STUDIES OF S-ANTIGEN - USE OF PROTEASES TO REVEAL A DOMINANT UVEITOGENIC SITE [J].
DUA, HS ;
HOSSAIN, P ;
BROWN, PAJ ;
MCKINNON, A ;
FORRESTER, JV ;
GREGERSON, DS ;
DONOSO, LA .
AUTOIMMUNITY, 1991, 10 (02) :153-163