OLIGONUCLEOTIDE CONJUGATES - ALTERATION OF THE PHARMACOKINETIC PROPERTIES OF ANTISENSE AGENTS

被引：27

作者：

MANOHARAN, M

TIVEL, KL

ANDRADE, LK

MOHAN, V

CONDON, TP

BENNETT, CF

COOK, PD

机构：

[1] Isis Pharmaceuticals

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1995年 / 14卷 / 3-5期

关键词：

D O I：

10.1080/15257779508012513

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cholic acid, cholesterol, several polyamines and polyethylene glycols were conjugated to antisense oligonucleotides targeted to human or murine intercellular adhesion molecule-1 (ICAM-1) mRNA to study their effects on cellular absorption.

引用

页码：969 / 973

页数：5

共 20 条

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