DIRECT CHROMATOGRAPHIC-SEPARATION OF THE ENANTIOMERS OF PHACLOFEN, SACLOFEN AND HYDROXYSACLOFEN - INFLUENCE OF THE ANIONIC MOIETY

被引:10
作者
VACCHER, C [1 ]
BERTHELOT, P [1 ]
DEBAERT, M [1 ]
机构
[1] UNIV LILLE 2,PHARM CHIM LAB,F-59006 LILLE,FRANCE
关键词
D O I
10.1016/0021-9673(93)83055-W
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The direct resolution of three analogues of baclofen (phaclofen, saclofen and hydroxysaclofen), potent gamma-aminobutyric acid B antagonists, is achieved by HPLC on an enantioselective crown ether column. The effects of the anionic group are discussed. Perchloric acid and methanol as organic modifier is used as mobile phase. The absolute configuration is proposed by comparison with enantiomers of baclofen (beta-p-chlorophenyl-gamma-aminobutyric acid). The above-mentioned compounds are easily and completely resolved.
引用
收藏
页码:213 / 218
页数:6
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