SYNTHESIS OF NEW IMIDAZOLE DERIVATIVES AS POTENTIAL INHIBITORS OF THROMBOXANE SYNTHETASE

被引：8

作者：

BANFI, A

SALA, A

SORESINETTI, PA

RUSSO, G

机构：

[1] UNIV MILAN,DIPARTIMENTO CHIM ORGAN & IND,I-20122 MILAN,ITALY

[2] CNR,CTR STUDIO SOSTANZE ORGAN NAT,I-20133 MILAN,ITALY

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 02期

关键词：

D O I：

10.1002/jhet.5570270219

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of new imidazole derivatives containing a carboxylic moiety such as succinic, adipic or benzoic into the side chain, is reported starting from the suitable imidazole intermediates. Copyright © 1990 Journal of Heterocyclic Chemistry

引用

页码：215 / 219

页数：5

共 12 条

[1] SIMPLE METHOD FOR SYNTHESIS OF AMIDES [J].

BARSTOW, LE ;

HRUBY, VJ .

JOURNAL OF ORGANIC CHEMISTRY, 1971, 36 (09) :1305-&

[2] SELECTIVE THROMBOXANE SYNTHETASE INHIBITORS .4. 2-(1H-IMIDAZOL-1-YLMETHYL) CARBOXYLIC-ACIDS OF BENZO[B]FURAN, BENZO[B]THIOPHENE, INDOLE, AND NAPHTHALENE [J].

CROSS, PE ;

DICKINSON, RP ;

PARRY, MJ ;

RANDALL, MJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (09) :1643-1650

[3]

DENNISS IS, 1978, TETRAHEDRON LETT, P295

[4]

GORMAN RR, 1977, P NATL ACAD SCI USA, V74, P4007, DOI 10.1073/pnas.74.9.4007

[5] SELECTIVE-INHIBITION OF THROMBOXANE-A2 BIOSYNTHESIS IN BLOOD-PLATELETS [J].

GRYGLEWSKI, RJ ;

ZMUDA, A ;

KORBUT, R ;

KRECIOCH, E ;

BIERON, K .

NATURE, 1977, 267 (5612) :627-628

[6] THROMBOXANES - NEW GROUP OF BIOLOGICALLY-ACTIVE COMPOUNDS DERIVED FROM PROSTAGLANDIN ENDOPEROXIDES [J].

HAMBERG, M ;

SVENSSON, J ;

SAMUELSSON, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (08) :2994-2998

[7] HIGHLY SELECTIVE INHIBITORS OF THROMBOXANE SYNTHETASE .1. IMIDAZOLE DERIVATIVES [J].

IIZUKA, K ;

AKAHANE, K ;

MOMOSE, DI ;

NAKAZAWA, M ;

TANOUCHI, T ;

KAWAMURA, M ;

OHYAMA, I ;

KAJIWARA, I ;

IGUCHI, Y ;

OKADA, T ;

TANIGUCHI, K ;

MIYAMOTO, T ;

HAYASHI, M .

JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (10) :1139-1148

[8] THROMBOXANE SYNTHETASE INHIBITORS (TXSI) - DESIGN, SYNTHESIS, AND EVALUATION OF A NOVEL SERIES OF OMEGA-PYRIDYLALKENOIC ACIDS [J].

KATO, K ;

OHKAWA, S ;

TERAO, S ;

TERASHITA, Z ;

NISHIKAWA, K .

JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (03) :287-294

[9] N-0164 INHIBITS GENERATION OF THROMBOXANE-A2-LIKE ACTIVITY FROM PROSTAGLANDIN ENDOPEROXIDES BY HUMAN PLATELET MICROSOMES [J].

KULKARNI, PS ;

EAKINS, KE .

PROSTAGLANDINS, 1976, 12 (03) :465-469

[10] STRUCTURE-ACTIVITY-RELATIONSHIPS IN AN IMIDAZOLE-BASED SERIES OF THROMBOXANE SYNTHASE INHIBITORS [J].

MANLEY, PW ;

ALLANSON, NM ;

BOOTH, RFG ;

BUCKLE, PE ;

KUZNIAR, EJ ;

LAD, N ;

LAI, SMF ;

LUNT, DO ;

TUFFIN, DP .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (09) :1588-1595

← 1 2 →