COMPARISON OF BROMISOVAL AND CARBROMAL IN RAT

被引：5

作者：

RAUWS, AG

机构：

[1] National Institute of Public Health, Utrecht

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1969年 / 21卷 / 05期

关键词：

D O I：

10.1111/j.2042-7158.1969.tb08251.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Distribution experiments in vitro and in vivo with bromisoval and carbromal have shown carbromal to be more lipophilic and cumulative in brain and fat tissue. The half‐life of bromisoval in the rat is approximately 2·5 h, that of carbromal is longer and variable. Stimulation and inhibition experiments revealed that both drugs are metabolized and follow different patterns. Carbromal toxicity is enhanced by bromide treatment, whereas bromisoval toxicity is not. The results show that carbromal is more toxic than bromisoval for the rat. 1969 Royal Pharmaceutical Society of Great Britain

引用

页码：287 / &

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