THE STEREOSELECTIVE HORNER-WITTIG REACTION WITH PHOSPHINE OXIDES - SYNTHESIS OF HINDERED Z-ALKENES VIA LUCHE REDUCTION

被引：31

作者：

HUTTON, G ^{[1
]}

JOLLIFF, T ^{[1
]}

MITCHELL, H ^{[1
]}

WARREN, S ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,CHEM LAB,CAMBRIDGE CB2 1EW,ENGLAND

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 43期

关键词：

D O I：

10.1016/0040-4039(95)01629-V

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The natural anti selectivity of the Homer-Wittig reaction with phosphine oxides is reduced when there is a branched chain next to the new C=C double bond. A better approach is Luche reduction of the corresponding ketones which gives high anti selectivity when the branched chain is placed on the side chain next to the phosphine oxide.

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收藏

页码：7905 / 7908

页数：4

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