IRREVERSIBLE ENZYME INHIBITORS .175. IRREVERSIBLE INHIBITION OF PURIFIED DIHYDROFOLIC REDUCTASE

被引：15

作者：

BAKER, BR

VERMEULEN, NM

机构：

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1970年 / 13卷 / 06期

关键词：

D O I：

10.1021/jm00300a028

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

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页码：1143 / +

页数：1

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[1] IRREVERSIBLE ENZYME INHIBITORS .105. DIFFERENTIAL IRREVERSIBLE INHIBITION OF VERTEBRATE DIHYDROFOLIC REDUCTASES BY DERIVATIVES OF 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-PHENYL-S-TRIAZINES SUBSTITUTED WITH A TERMINAL SULFONYL FLUORIDE [J].

BAKER, BR ;

LOURENS, GJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (06) :1113-+

[2] IRREVERSIBLE ENZYME INHIBITORS .109. CANDIDATE IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-PHENYL-S-TRIAZINE .3. [J].

BAKER, BR ;

LOURENS, GJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (01) :26-&

[3] TISSUE-SPECIFIC IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE [J].

BAKER, BR .

ACCOUNTS OF CHEMICAL RESEARCH, 1969, 2 (05) :129-+

[4] IRREVERSIBLE ENZYME INHIBITORS .151. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 5-(P-AMINOPHENYLBUTYL)-2,4-DIAMINOPYRIMIDINES WITH A TERMINAL SULFONYL FLUORIDE [J].

BAKER, BR ;

MEYER, RB .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (02) :224-&

[5] IRREVERSIBLE ENZYME INHIBITORS .159. EFFECT OF SUBSTITUTION ON TRANSPORT AND ISOZYME SPECIFICITY OF P-(4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZIN-L-YL)-O-CHLOROPHENOXYACETAMIDO-BENZENESULFONYL FLUORIDE, AN ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITOR OF DIHYDROFOLIC REDUCTASE [J].

BAKER, BR ;

ASHTON, WT .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (05) :894-&

[6] IRREVERSIBLE ENZYME INHIBITORS .166. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 2,4-DIAMINO-5-(3,4-DICHLOROPHENYL)PYRIMIDINE WITH 6 SUBSTITUENTS AND SOME FACTORS IN THEIR CELL WALL TRANSPORT [J].

BAKER, BR ;

VERMEULE.NM .

JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (01) :82-&

[7] IRREVERSIBLE ENZYME INHIBITORS .158. EFFECT OF BRIDGE MODIFICATION ON SELECTIVE IRREVERSIBLE INHIBITION OF DIHYDROFOLIC REDUCTASE FROM L1210 MOUSE LEUKEMIA AND LIVER BY 2,4-DIAMINO-5-(3,4-DICHLOROPHENYL)-6-[P-(M-FLUOROSULFONYLBENZAMIDOMETHYL)PHENOXYMETHYL]PYRIMIDINE .2. [J].

BAKER, BR ;

VERMEULEN, NM .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (04) :684-+

[8] IRREVERSIBLE ENZYME INHIBITORS .155. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 1-[4-(OMEGA-AMINOALKOXY)-3-CHLOROPHENYL]-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZINES BEARING A TERMINAL SULFONYL FLUORIDE [J].

BAKER, BR ;

JANSON, EE .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (04) :672-&

[9] IRREVERSIBLE ENZYME INHIBITORS . 143 . ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 5-(P-AMINOPHENOXYPROPYL)-2,4-DIAMINO-6-METHYLPYRIMIDINE WITH A TERMINAL SULFONYL FLUORIDE [J].

BAKER, BR ;

MEYER, RB .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (01) :108-&

[10] IRREVERSIBLE ENZYME INHIBITORS . 140 . ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS DERIVED FROM 1-(3-CHLOROPHENYL)-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZINE [J].

BAKER, BR ;

LOURENS, GJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (01) :95-&