BIOTRANSFORMATIONS OF AROMATIC DINITRILES USING RHODOCOCCUS-EQUI CELLS

被引：14

作者：

MARTINKOVA, L

OLSOVSKY, P

PREPECHALOVA, I

KREN, V

机构：

[1] Institute of Microbiology, Academy of Science of the Czech Republic, Prague, 4

来源：

BIOTECHNOLOGY LETTERS | 1995年 / 17卷 / 11期

关键词：

D O I：

10.1007/BF00128389

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Short incubation (1 - 5 h) of aromatic dinitriles with resting cells of Rhodococcus equi A4 produces the corresponding cyano amides in 48 - 81 % yield. The substrate reactivity decreases in order 1,4- greater than or equal to 1,3- > 1,2-disubstitution. Prolonged treatment (20 - 50 h) is needed to achieve the conversion to acid or for transformation of the second cyano group.

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页码：1219 / 1222

页数：4

相关论文

共 11 条

[1] SELECTIVE HYDROLYSIS OF NITRILES UNDER MILD CONDITIONS BY AN ENZYME [J].

COHEN, MA ;

SAWDEN, J ;

TURNER, NJ .

TETRAHEDRON LETTERS, 1990, 31 (49) :7223-7226

[2] ENANTIOSELECTIVE HYDROLYSIS OF NITRILES AND AMIDES USING AN IMMOBILIZED WHOLE CELL SYSTEM [J].

COHEN, MA ;

PARRATT, JS ;

TURNER, NJ .

TETRAHEDRON-ASYMMETRY, 1992, 3 (12) :1543-1546

[3] REGIOSELECTIVE HYDROLYSIS OF AROMATIC DINITRILES USING A WHOLE-CELL CATALYST [J].

CROSBY, J ;

MOILLIET, J ;

PARRATT, JS ;

TURNER, NJ .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1994, (13) :1679-1687

[4] CHEMOSELECTIVE ENZYMATIC-HYDROLYSIS OF ALIPHATIC AND ALICYCLIC NITRILES [J].

DERAADT, A ;

KLEMPIER, N ;

FABER, K ;

GRIENGL, H .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1992, (01) :137-140

[5]

DERAADT A, 1993, J ORG CHEM, V3, P179

[6]

DIGERONIMO MJ, 1976, APPL ENVIRON MICROB, V31, P900, DOI 10.1128/AEM.31.6.900-906.1976

[7] ELECTRONIC SUBSTITUENT EFFECTS IN THE NITRILASE-CATALYZED HYDROLYSIS OF PARASUBSTITUTED BENZYL CYANIDES [J].

GERESH, S ;

GIRON, Y ;

GILBOA, Y ;

GLASER, R .

TETRAHEDRON, 1993, 49 (44) :10099-10102

[8] ENZYMATIC-HYDROLYSIS OF NITRILES AND DINITRILES [J].

HONICKESCHMIDT, P ;

SCHNEIDER, MP .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1990, (08) :648-650

[9] ENZYMATIC-HYDROLYSIS OF HETEROCYCLIC NITRILES [J].

KLEMPIER, N ;

DERAADT, A ;

GRIENGL, H ;

HEINISCH, G .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1992, 29 (01) :93-95

[10] SELECTIVE TRANSFORMATION OF NITRILES INTO AMIDES AND CARBOXYLIC-ACIDS BY AN IMMOBILIZED NITRILASE [J].

KLEMPIER, N ;

DERAADT, A ;

FABER, K ;

GRIENG, H .

TETRAHEDRON LETTERS, 1991, 32 (03) :341-344