Notch信号通路在B细胞分化发育以及B细胞淋巴瘤中作用的研究进展

被引：10

作者：

任文汇 ^{[1
]}

王春梅 ^{[2
]}

李楠 ^{[1
]}

机构：

[1] 第二军医大学免疫学研究所暨医学免疫学国家重点实验室

[2] 中国医学科学院基础医学研究所

来源：

中国肿瘤生物治疗杂志 | 2016年 / 23卷 / 02期

关键词：

Notch信号; B细胞; 分化发育; B细胞淋巴瘤;

D O I：

暂无

中图分类号：

R733.1 [网状内皮系统肿瘤];

学科分类号：

100117 [系统生物医学];

摘要：

Notch信号通路是一种在进化中较为保守的信号通路,在多种生命活动中发挥重要作用。目前研究认为,Notch信号参与了免疫细胞的生长、分化和发育等多个环节的调控,其在B细胞的分化发育过程以及相关肿瘤的发生发展中起到重要的调控作用。本文对Notch信号在B细胞的不同分化发育阶段如淋巴祖细胞(common lymphoid progenitor,CLP)、边缘区B细胞(marginal zone B cell,MZ B)、滤泡B细胞(follicular B cell,FO B)、B-1 B细胞,以及B细胞淋巴瘤中的作用进行了综述。

引用

收藏

页码：282 / 286

页数：5

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