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A poly phenolicfraction from grape seeds causes irreversib le growth inh ib i-tion of breast carc inom aMDA-MB468 cells by inh ib ition m i-togen-activated prote in k inases activation and induc ing G1arrest and d ifferentiation. Agarwal G,Sharm a Y,Zhao J,et al. G lin Cancer Res . 2000