青霉素酰化酶制备6-APA的研究进展

被引：10

作者：

张业旺 ^{[1
]}

谭强 ^{[2
]}

刘瑞江 ^{[1
]}

徐秀泉 ^{[1
]}

徐希明 ^{[1
]}

机构：

[1] 江苏大学药学院

[2] 广西中医学院药学院

来源：

中国抗生素杂志 | 2008年 / 07期

关键词：

青霉素酰化酶; 6-APA; 双水相系统; 水-有机相系统; 离子液体; 反应器设计;

D O I：

10.13461/j.cnki.cja.004238

中图分类号：

R943 [制剂学];

学科分类号：

100602 ; 100702 ;

摘要：

6-氨基青霉烷酸(6-APA)是重要的抗生素药物中间体之一,目前均采用青霉素酰化酶酶促裂解青霉素获得。本文介绍近年来青霉素酰化酶催化青霉素水解的研究进展,青霉素酰化酶的性质及其催化机理,青霉素酰化酶的固定化方法,青霉素酰化酶反应器的设计,反应介质工程的研究进展。

引用

页码：385 / 391

页数：7

共 34 条

[21]

A new, mild cross‐linking methodology to prepare cross‐linked enzyme aggregates[J] . CesarMateo,José M.Palomo,Luuk M.van Langen,Fredvan Rantwijk,Roger A.Sheldon.Biotechnol. Bioeng. . 2004 (3)

[22] Continuous penicillin G hydrolysis in an electro-membrane reactor with immobilized penicillin G acylase [J].

Zadrazil, A ;

Chmelíková, R ;

Hasal, P .

BIOTECHNOLOGY LETTERS, 2003, 25 (06) :485-490

[23] Penicillin G hydrolysis in an electro-membrane reactor with immobilized penicillin G acylase [J].

Pribyl, M ;

Chmelíková, R ;

Hasal, P ;

Marek, M .

ENZYME AND MICROBIAL TECHNOLOGY, 2003, 33 (06) :793-801

[24]

Continuous enzymatic penicillin G hydrolysis in countercurrent water–butyl acetate biphasic systems[J] . J.L. den Hollander,M. Zomerdijk,A.J.J. Straathof,L.A.M. van der Wielen.Chemical Engineering Science . 2002 (9)

[25] Chromogenic analogues of penicillin dihydroF and penicillin K for the continuous spectrophotometric determination of aliphatic penicillin acylase activity [J].

Arroyo, M ;

Torres-Guzmán, R ;

Torres-Bacete, J ;

de la Mata, I ;

Castillón, MP ;

Acebal, C .

BIOTECHNOLOGY LETTERS, 2002, 24 (13) :1045-1048

[26] Equilibrium modeling of extractive enzymatic hydrolysis of penicillin G with concomitant 6-aminopenicillanic acid crystallization [J].

Diender, MB ;

Straathof, AJJ ;

van der Does, T ;

Ras, C ;

Heijnen, JJ .

BIOTECHNOLOGY AND BIOENGINEERING, 2002, 78 (04) :395-402

[27]

Crystal structures of penicillin acylase enzyme-substrate complexes: structural insights into the catalytic mechanism 1 1 Edited by K. Nagai[J] . Colin E McVey,Martin A Walsh,G.Guy Dodson,Keith S Wilson,James A Brannigan.Journal of Molecular Biology . 2001 (1)

[28] A new support for the immobilization of penicillin acylase [J].

Jing, H ;

Li, XF ;

Evans, DG ;

Duan, X ;

Li, CY .

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2000, 11 (01) :45-53

[29]

Eupergit? C, a carrier for immobilization of enzymes of industrial potential[J] . Ephraim Katchalski-Katzir,Dieter M Kraemer.Journal of Molecular Catalysis. B, Enzymatic . 2000 (1)

[30]

Penicillin G amidase in low-water media: immobilisation and control of water activity by means of celite rods[J] . Luigi De Martin,Cynthia Ebert,Gianpiero Garau,Lucia Gardossi,Paolo Linda.Journal of Molecular Catalysis. B, Enzymatic . 1999 (4)

← 1 2 3 4 →