Applying Flow Chemistry: Methods, Materials, and Multistep Synthesis

被引:412
作者
McQuade, D. Tyler [1 ,3 ]
Seeberger, Peter H. [1 ,2 ]
机构
[1] Max Planck Inst Colloids & Interfaces, Dept Biomol Syst, D-14476 Golm, Germany
[2] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany
[3] Florida State Univ, Dept Chem & Biochem, Tallahassee, FL 32306 USA
关键词
SINGLE-POLYMER DYNAMICS; MICROREACTOR TECHNOLOGY; MICROFLUIDIC SYSTEM; HECK REACTION; OPTIMIZATION; GENERATION; PARADIGM; REACTORS; BATCH; REVOLUTION;
D O I
10.1021/jo400583m
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The synthesis of complex molecules requires control over both chemical reactivity and reaction conditions. While reactivity drives the majority of chemical discovery, advances in reaction condition control have accelerated method development/discovery. how flow reactors have enabled chemical advances in our groups in the areas of single stage reactions, materials synthesis, and multistep reactions. In each section, we detail the lessons learned and propose future directions
引用
收藏
页码:6384 / 6389
页数:6
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