Biopsy with Thermally-Responsive Untethered Microtools

被引:221
作者
Gultepe, Evin [1 ]
Randhawa, Jatinder S. [1 ]
Kadam, Sachin [1 ]
Yamanaka, Sumitaka [2 ]
Selaru, Florin M. [2 ]
Shin, Eun J. [2 ]
Kalloo, Anthony N. [2 ]
Gracias, David H. [1 ,3 ]
机构
[1] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA
[2] Johns Hopkins Univ, Dept Med, Div Gastroenterol & Hepatol, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA
基金
美国国家科学基金会;
关键词
actuators; stimuli responsive materials; robotics; self-assembly; self-folding; microsurgery;
D O I
10.1002/adma.201203348
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Thermally activated, untethered microgrippers can reach narrow conduits in the body and be used to excise tissue for diagnostic analyses. As depicted in the figure, the feasibility of an in vivo biopsy of the porcine bile duct using untethered microgrippers is demonstrated.
引用
收藏
页码:514 / 519
页数:6
相关论文
共 52 条
[1]   Membrane folding to achieve three-dimensional nanostructures: Nanopatterned silicon nitride folded with stressed chromium hinges [J].
Arora, WJ ;
Nichol, AJ ;
Smith, HI ;
Barbastathis, G .
APPLIED PHYSICS LETTERS, 2006, 88 (05) :1-3
[2]   Enzymatically Triggered Actuation of Miniaturized Tools [J].
Bassik, Noy ;
Brafman, Alla ;
Zarafshar, Aasiyeh M. ;
Jamal, Mustapha ;
Luvsanjav, Delgermaa ;
Selaru, Florin M. ;
Gracias, David H. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (46) :16314-16317
[3]   Shape-memory polymers [J].
Behl, Marc ;
Lendlein, Andreas .
MATERIALS TODAY, 2007, 10 (04) :20-28
[4]   Out-of-plane high-Q inductors on low-resistance silicon [J].
Chua, CL ;
Fork, DK ;
Van Schuylenbergh, K ;
Lu, JP .
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, 2003, 12 (06) :989-995
[5]   Robotic versus manual control in magnetic steering of an endoscopic capsule [J].
Ciuti, G. ;
Donlin, R. ;
Valdastri, P. ;
Arezzo, A. ;
Menciassi, A. ;
Morino, M. ;
Dario, P. .
ENDOSCOPY, 2010, 42 (02) :148-152
[6]   A Wireless and Batteryless 10-Bit Implantable Blood Pressure Sensing Microsystem With Adaptive RF Powering for Real-Time Laboratory Mice Monitoring [J].
Cong, Peng ;
Chaimanonart, Nattapon ;
Ko, Wen H. ;
Young, Darrin J. .
IEEE JOURNAL OF SOLID-STATE CIRCUITS, 2009, 44 (12) :3631-3644
[7]   A wireless microsystem for the remote sensing of pressure, temperature, and relative humidity [J].
DeHennis, AD ;
Wise, KD .
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, 2005, 14 (01) :12-22
[8]   Minimally invasive single-site surgery for the digestive system: A technological review [J].
Dhumane, Parag W. ;
Diana, Michele ;
Leroy, Joel ;
Marescaux, Jacques .
JOURNAL OF MINIMAL ACCESS SURGERY, 2011, 7 (01) :40-51
[9]   First-in-Human Testing of a Wirelessly Controlled Drug Delivery Microchip [J].
Farra, Robert ;
Sheppard, Norman F., Jr. ;
McCabe, Laura ;
Neer, Robert M. ;
Anderson, James M. ;
Santini, John T., Jr. ;
Cima, Michael J. ;
Langer, Robert .
SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (122)
[10]   Toward a miniaturized mechanical surgeon [J].
Fernandes, Rohan ;
Gracias, David H. .
MATERIALS TODAY, 2009, 12 (10) :14-20