Association between the brain-derived neurotrophic factor (BDNF) gene and Schizophrenia in the Chinese population

被引：38

作者：

Chen, QY

Chen, Q

Feng, GY

Wan, CL

Lindpaintner, K

Wang, LJ

Chen, ZX

Gao, ZS

Tang, JS

Li, XW

He, L

机构：

[1] Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China

[3] Chinese Acad Sci, SIBS, Inst Nutr Sci, Shanghai 200030, Peoples R China

[4] Shanghai Inst Mental Hlth, Shanghai 200030, Peoples R China

[5] Roche China Ltd, Shanghai 201203, Peoples R China

[6] Shenyang Tiexi Inst Mental Hlth, Liaoning, Peoples R China

[7] Shandong Inst Mental Hlth, Shandong, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2006年 / 397卷 / 03期

基金：

中国国家自然科学基金;

关键词：

BDNF; case-control; association; Schizophrenia; Chinese;

D O I：

10.1016/j.neulet.2005.12.033

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain-derived neurotrophic factor (BDNF) belongs to a family of the neurotrophin which plays important roles in the development of the brain. BDNF hits been suggested as a factor that increases the risk of schizophrenia. In this study, we genotyped three single nucleotide polymorphisms (SNPs) in the BDNF gene using a set sample of Han Chinese subjects consisting of 560 schizophrenes and 576 controls. No significant differences were found for either the genotype or allele distribution of analyzed polymorphisms, nor was any gender-specific association found. Thus, our data suggest that the BDNF gene may not be an important factor in susceptibility to schizophrenia. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：285 / 290

页数：6

共 59 条

[21] Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia [J].