RNA Interference Pathways in Fungi: Mechanisms and Functions

被引：168

作者：

Chang, Shwu-Shin ^{[1
]}

Zhang, Zhenyu ^{[1
]}

Liu, Yi ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Physiol, Dallas, TX 75390 USA

来源：

ANNUAL REVIEW OF MICROBIOLOGY, VOL 66 | 2012年 / 66卷

关键词：

small noncoding RNA; Schizosaccharomyces pombe; Neurospora; DOUBLE-STRANDED-RNA; CHESTNUT BLIGHT FUNGUS; NEUROSPORA-CRASSA; UNPAIRED DNA; CRYPTOCOCCUS-NEOFORMANS; HISTONE MODIFICATION; PATHOGENIC FUNGUS; ANTIVIRAL DEFENSE; GENE-EXPRESSION; POLYMERASE-II;

D O I：

10.1146/annurev-micro-092611-150138

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

RNA interference (RNAi) is a conserved eukaryotic gene regulatory mechanism that uses small noncoding RNAs to mediate posttranscriptional/transcriptional gene silencing. The fission yeast Schizosaccharomyces pombe and the filamentous fungus Neurospora crassa have served as important model systems for RNAi research. Studies on these two organisms and other fungi have contributed significantly to our understanding of the mechanisms and functions of RNAi in eukaryotes. In addition, surprisingly diverse RNAi-mediated processes and small RNA biogenesis pathways have been discovered in fungi. In this review, we give an overview of different fungal RNAi pathways with a focus on their mechanisms and functions.

引用

页码：305 / 323

页数：19

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