Ligations of N-acyl tryptophan units to give native peptides via 7-, 10-, 11-and 12-membered cyclic transition states

被引：17

作者：

Popov, Vadim ^{[1
]}

Panda, Siva S. ^{[1
]}

Katritzky, Alan R. ^{[1
,2
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

[2] King Abdulaziz Univ, Dept Chem, Jeddah 21589, Saudi Arabia

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 10期

关键词：

UNPROTECTED PEPTIDES; CHEMICAL LIGATION; STAUDINGER LIGATION; BUILDING-BLOCKS; PROTEINS; AUXILIARIES; DENDRIMERS; PROTEASE; LINKER; SERINE;

D O I：

10.1039/c3ob27421g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Acyl tryptophan isopeptides undergo acyl transfer in chemical ligations via 7-, 10-, 11- and 12-membered cyclic transition states to yield natural peptides, representing the first examples of successful isopeptide ligations from N-acyl tryptophan units.

引用

页码：1594 / 1597

页数：4

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