Stereocontrolled intermolecular radical additions to methylidenepiperazine-2,5-diones

被引：16

作者：

Chai, CLL ^{[1
]}

King, AR

机构：

[1] Australian Natl Univ, The Faculties, Dept Chem, Canberra, ACT 0200, Australia

[2] Australian Natl Univ, Inst Adv Studies, Res Sch Chem, Canberra, ACT 0200, Australia

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1999年 / 09期

关键词：

D O I：

10.1039/a900771g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of latent amino acid functionalities for the syntheses of methylidenepiperazine-2,5-diones is reported. These piperazinediones are potential chiral templates in the synthesis of functionalised piperazinediones and amino acids. Carbon-carbon bond formation utilising radical addition reactions between the methylidenepiperazinediones and a number of alkyl radicals resulted in good yields of the addition adduct. Moderate to high diastereoselectivities were observed and factors controlling the chiral induction are discussed here.

引用

页码：1173 / 1182

页数：10

共 41 条

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