Exosomes in head and neck cancer: Roles, mechanisms and applications

被引：31

作者：

Cao, Jun ^{[1
]}

Zhang, Mengdi ^{[4
,5
]}

Xie, Feng ^{[2
,3
]}

Lou, Jianlin ^{[6
]}

Zhou, Xiaoxue ^{[1
,4
,5
]}

Zhang, Long ^{[4
,5
]}

Fang, Meiyu ^{[1
]}

Zhou, Fangfang ^{[2
,3
]}

机构：

[1] Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp,Chinese Acad Sci, Dept Rare & Head & Neck Oncol,Inst Canc Res & Bas, Hangzhou 310022, Zhejiang, Peoples R China

[2] Soochow Univ, Inst Biol, Suzhou 215123, Peoples R China

[3] Soochow Univ, Inst Med Sci, Suzhou 215123, Peoples R China

[4] Zhejiang Univ, Life Sci Inst, MOE Lab Biosyst Homeostasis & Protect, Hangzhou 310058, Peoples R China

[5] Zhejiang Univ, Innovat Ctr Cell Signaling Network, Life Sci Inst, Hangzhou 310058, Peoples R China

[6] Univ Chinese Acad Sci, Zhejiang Canc Hosp, Chinese Acad Sci, Canc Hosp,Dept Head & Neck Surg,Inst Canc Res & B, Hangzhou 310022, Zhejiang, Peoples R China

来源：

CANCER LETTERS | 2020年 / 494卷

基金：

美国国家科学基金会;

关键词：

Exosomes; Head and neck carcinoma; Biomarker; Therapy resistance; SQUAMOUS-CELL CARCINOMA; LONG NONCODING RNAS; TUMOR-DERIVED EXOSOMES; PAPILLARY THYROID-CARCINOMA; NASOPHARYNGEAL CARCINOMA; EMERGING ROLES; SERUM EXOSOMES; CIRCULAR RNAS; EXPRESSION; MICROENVIRONMENT;

D O I：

10.1016/j.canlet.2020.07.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Exosomes are extracellular vesicles with a diameter of 30-100 nm that exist stably in various body fluids, including the blood, cerebrospinal fluid, urine, saliva, and serous cavity effusion. Compared with other vesicles, exosomes have a unique double-layer saclike structure and an endosomal origin. Depending on the physiological state of donor cells, there is heterogeneity in the bioactive substances present in exosomes, including proteins, RNA, DNA, lipids, and metabolites, providing a rich source of potential biomarkers for disease diagnosis. In head and neck cancer (HNC), exosomes have applications in disease diagnosis and prognosis based on liquid biopsy. Nonetheless, the functions and mechanisms of exosomes in HNC still remain unclear. Recent studies have elucidated the substances and signals transmitted between cancer cells using exosomes and have discussed tumor occurrence, development, metastasis, immune regulation, and drug resistance regulated by exosomes in HNC. In this review, we discuss these recent findings and highlight the significant role of exosomes in HNC, with a focus on the mechanism of tumor progression and the potential clinical value of exosomes as biomarkers and therapeutic targets.

引用

页码：7 / 16

页数：10

共 108 条

[61]

AHNS Series: Do you know your guidelines? Principles of surgery for head and neck cancer: A review of the National Comprehensive Cancer Network guidelines [J].