An improved synthesis of α-carbolines under microwave irradiation

被引：79

作者：

Vera-Luque, P ^{[1
]}

Alajarín, R ^{[1
]}

Alvarez-Builla, J ^{[1
]}

Vaquero, JJ ^{[1
]}

机构：

[1] Univ Alcala de Henares, Dept Quim Organ, Madrid 28871, Spain

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 03期

关键词：

D O I：

10.1021/ol052552y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-Carbolines are interesting core structures for designing DNA-interacting small molecules. However, these compounds are not commercially available and their synthetic methods are low yielding or time consuming. The shortest synthetic route, the modified Graebe-Ullmann reaction, has been optimized by using microwave heating in four different types of apparatus to give shorter reaction times and enhanced yields. Optimized conditions enabled the preparation of a small library of alpha-carbolines.

引用

页码：415 / 418

页数：4

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