Synthesis and antitumor activity of icogenin and its analogue

被引：25

作者：

Hou, SJ

Xu, P

Zhou, L

Yu, DQ

Lei, PS

机构：

[1] Peking Union Med Coll, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, Inst Mat Med, Beijing 100050, Peoples R China

[2] Chinese Acad Med Sci, Beijing 100050, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 09期

关键词：

iogenin; glycosylation; cytotoxicity;

D O I：

10.1016/j.bmcl.2006.01.074

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Natural saponin icogenin, namely 25(S)-22-O-methyl-furost-5-en-3 beta,26-dio-3-O-alpha-L-rhamnopyranosyl-(1 --> 2)-[beta-D-glucopyranosyl-(1 --> 3)]-beta-D-glucopyranoside, and one of its analogues, 25(S)-22-O-methyl-furost-5-en-3 beta,26-dio-3-O-alpha-L-rhamnopyranosyl-(1 --> 2)-[beta-D-glucopyranosyl-(1 --> 3)]-alpha-D-glucopyranoside, were first synthesized via line strategy and convergent approach, respectively. It was observed that icogenin and its analogue show potent antitumor activity in vitro. (C) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2454 / 2458

页数：5

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