The Studies on Pharmacophore Model of K+ Channel Opener

被引：1

作者：

Chen Hongming ^{[1
]}

Zhou Jiaju ^{[1
]}

Xie Guirong ^{[1
]}

Pang Suhua ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem Met, Lab Comp Chemostry, Beijing 100080, Peoples R China

来源：

ACTA PHYSICO-CHIMICA SINICA | 1997年 / 13卷 / 02期

关键词：

K+ channel opener; CoMFA; Pharmacophore model; QSAR;

D O I：

10.3866/PKU.WHXB19970202

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this paper, a set of ATP sensitive K+ channel openers (KCO) whose structure are different, were investigated with the aim to develope our previously defined KCO's pharmacophore model.To validate the effectiveness of the pharmacophore model, A Comparative molecule field analysis (CoMFA) was proceeded, aligning the molecules according to the requirement of the model, and good results were obtained. This pharmacophore model may be a start point to design new KCO compounds.

引用

页码：101 / 105

页数：5

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