Copper(I) Iodide/Boron Trifluoride Etherate-Cocatalyzed Aerobic Dehydrogenative Reactions Applied in the Synthesis of Substituted Heteroaromatic Imidazo[1,2-a]pyridines

被引：81

作者：

Cai, Zhong-Jian ^{[1
]}

Wang, Shun-Yi ^{[1
]}

Ji, Shun-Jun ^{[1
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2013年 / 355卷 / 13期

基金：

中国国家自然科学基金;

关键词：

C(sp(3))H functionalization; copper; dehydrogenative coupling; imidazo[1; 2-a]pyridines; oxygen; ONE-POT SYNTHESIS; MOLECULAR-OXYGEN; ALPHA-KETOAMIDES; BOND FORMATION; CATALYZED OXIDATION; COUPLING REACTIONS; OXIDASE CATALYSIS; FACILE SYNTHESIS; N-HETEROCYCLES; C-C;

D O I：

10.1002/adsc.201300333

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Compared with the well-known palladium-catalyzed oxidative dehydrogenation coupling reactions, similar transforms initiated by copper/oxygen have attracted more and more attention. We have investigated a novel construction of heteroaromatic imidazo[1,2-a]pyridines through copper(I) iodide/boron trifluoride etherate/oxygen-mediated dehydrogenative reactions of aryl alkyl or alkyl alkyl ketones with 2-aminopyridines. Four hydrogen atoms are removed and two new CN bonds are formed in one step via the imine formation and oxidative C(sp(3))H functionalization.

引用

页码：2686 / 2692

页数：7

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