Coupling of Two Multistep Catalytic Cycles for the One-Pot Synthesis of Propargylamines from Alcohols and Primary Amines on a Nanoparticulated Gold Catalyst

被引：54

作者：

Corma, Avelino ^{[1
]}

Navas, Javier ^{[1
]}

Sabater, Maria J. ^{[1
]}

机构：

[1] Inst Tecnol Quim UPV CSIC, Valencia 46022, Spain

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2012年 / 18卷 / 44期

关键词：

alkylation; domino reactions; gold; hydrogen transfer; propargylamines; CHEMOSELECTIVE HYDROGENATION; AEROBIC OXIDATION; TERMINAL ALKYNES; NITRO-COMPOUNDS; N-ALKYLATION; EFFICIENT; SELECTIVITY; ACTIVATION; COMPLEXES; REDUCTION;

D O I：

10.1002/chem.201201837

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A one-pot reaction was performed with a nanoparticulated gold catalyst. A secondary amine is formed through N-monoalkylation of a primary amine with an alcohol by a borrowing hydrogen methodology in a three-step reaction. The secondary amine formed enters into a second A(3)-coupling cycle to give propargylamines. The multistep reaction requires a gold species formed and stabilized on a ceria surface.

引用

页码：14150 / 14156

页数：7

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