Effects of cerium oxide nanoparticles on the growth of keratinocytes, fibroblasts and vascular endothelial cells in cutaneous wound healing

被引：297

作者：

Chigurupati, Srinivasulu ^{[1
,2
,3
]}

Mughal, Mohamed R. ^{[1
]}

Okun, Eitan ^{[1
,6
]}

Das, Soumen ^{[3
]}

Kumar, Amit ^{[3
]}

McCaffery, Michael ^{[4
,5
]}

Seal, Sudipta ^{[3
]}

Mattson, Mark P. ^{[1
]}

机构：

[1] NIA, Neurosci Lab, Intramural Res Program, Baltimore, MD 21224 USA

[2] Univ Cent Florida, Burnett Sch Biomed Sci, Dept Mol Biol & Microbiol, Orlando, FL 32816 USA

[3] Univ Cent Florida, Nanosci Technol Ctr NSTC, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA

[4] Johns Hopkins Univ, Engn Oncol Ctr, Dept Biol, Integrated Imaging Ctr, Baltimore, MD 21218 USA

[5] Johns Hopkins Univ, Inst NanoBiotechnol, Baltimore, MD 21218 USA

[6] Bar Ilan Univ, Leslie & Susan Gonda Multidisciplinary Brain Res, Mina & Everard Goodman Fac Life Sci, IL-52900 Ramat Gan, Israel

来源：

BIOMATERIALS | 2013年 / 34卷 / 09期

基金：

美国国家科学基金会;

关键词：

Cerium oxide nanoparticles; Vascular endothelial cells; Keratinocytes; Fibroblasts; Wound healing; Oxidative stress; TUBBY MICE; NANOCERIA; ANTIOXIDANT; ANGIOGENESIS; DEGENERATION; MODULATION; PROTECTION; PROTEINS; REPAIR;

D O I：

10.1016/j.biomaterials.2012.11.061

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Rapid and effective wound healing requires a coordinated cellular response involving fibroblasts, keratinocytes and vascular endothelial cells (VECs). Impaired wound healing can result in multiple adverse health outcomes and, although antibiotics can forestall infection, treatments that accelerate wound healing are lacking. We now report that topical application of water soluble cerium oxide nanoparticles (Nanoceria) accelerates the healing of full-thickness dermal wounds in mice by a mechanism that involves enhancement of the proliferation and migration of fibroblasts, keratinocytes and VECs. The Nanoceria penetrated into the wound tissue and reduced oxidative damage to cellular membranes and proteins, suggesting a therapeutic potential for topical treatment of wounds with antioxidant nanoparticles. Published by Elsevier Ltd.

引用

页码：2194 / 2201

页数：8

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