Enantioselectivity of the nitrile hydratase from Rhodococcus equi A4 towards substituted (R,S)-2-arylpropionitriles

被引：19

作者：

Martinkova, L ^{[1
]}

Stolz, A ^{[1
]}

Knackmuss, HJ ^{[1
]}

机构：

[1] UNIV STUTTGART,INST MICROBIOL,D-70550 STUTTGART,GERMANY

来源：

BIOTECHNOLOGY LETTERS | 1996年 / 18卷 / 09期

关键词：

D O I：

10.1007/BF00129734

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Rhodococcus equi A4 cells containing a nitrile hydratase and an amidase converted (R, S)-2-(4-methoxyphenyl)-propionitrile into the corresponding (S)-acid (e.e. 87%) and (R)-nitrile (e.e. > 95%) in 49% yield. The same reaction using (R, S)-2-(4- chlorophenyl)-propionitrile gave the (S)-acid (e.e. > 95%) and (R)-nitrile (e.e. 52%) in 20 and 34% yield, respectively.

引用

页码：1073 / 1076

页数：4

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