Encoding and Decoding Cellular Information through Signaling Dynamics

被引：574

作者：

Purvis, Jeremy E. ^{[1
]}

Lahav, Galit ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA

来源：

CELL | 2013年 / 152卷 / 05期

基金：

美国国家卫生研究院;

关键词：

NERVE GROWTH-FACTOR; ACTIVATED PROTEIN-KINASE; P53-MDM2 FEEDBACK LOOP; KAPPA-B DYNAMICS; TEMPORAL CONTROL; MAP KINASE; PC12; CELLS; SPATIOTEMPORAL CONTROL; CALCIUM OSCILLATIONS; CANCER-CELLS;

D O I：

10.1016/j.cell.2013.02.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A growing number of studies are revealing that cells can send and receive information by controlling the temporal behavior (dynamics) of their signaling molecules. In this Review, we discuss what is known about the dynamics of various signaling networks and their role in controlling cellular responses. We identify general principles that are emerging in the field, focusing specifically on how the identity and quantity of a stimulus is encoded in temporal patterns, how signaling dynamics influence cellular outcomes, and how specific dynamical patterns are both shaped and interpreted by the structure of molecular networks. We conclude by discussing potential functional roles for transmitting cellular information through the dynamics of signaling molecules and possible applications for the treatment of disease.

引用

页码：945 / 956

页数：12

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