Continuous Multiple Liquid-Liquid Separation: Diazotization of Amino Acids in Flow

被引：87

作者：

Hu, Dennis X. ^{[1
]}

O'Brien, Matthew ^{[1
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 16期

基金：

英国工程与自然科学研究理事会;

关键词：

MULTISTEP ORGANIC-SYNTHESIS; ENABLING TECHNOLOGY; SUPPORTED REAGENTS; SINGLET OXYGEN; REACTOR; PHOTOCHEMISTRY; SCAVENGERS; CATALYSIS; OXIDATION; PARADIGM;

D O I：

10.1021/ol301930h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A second-generation laboratory-scale, modular liquid-liquid separation device based on computer-controlled high-pressure pumps and a high. resolution digital camera has been invented. The diazotization of amino acids to produce valuable chiral hydroxyacids is demonstrated in flow for the first time. The use of a triple-separator system in conjuction with the developed diazotization process allows the safe and efficient production and automated isolation of multigram quantities of valuable chiral hydroxyacids.

引用

页码：4246 / 4249

页数：4

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