Dendrimer-scaffold-based electron-beam patterning of biomolecules

被引:29
作者
Bhatnagar, P
Mark, SS
Kim, I
Chen, HY
Schmidt, B
Lipson, M
Batt, CA
机构
[1] Cornell Univ, Dept Biomed Engn, Ithaca, NY 14853 USA
[2] Cornell Univ, Dept Microbiol, Ithaca, NY 14853 USA
[3] Cornell Univ, Dept Microbiol, Ithaca, NY 14853 USA
[4] Cornell Univ, Dept Elect & Comp Engn, Ithaca, NY 14853 USA
关键词
D O I
10.1002/adma.200501170
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A layer-by-layer approach for patterning biomolecules on dendrimer scaffolds using electron-beam lithography has been developed (see Figure). A self-assembled poly(ethylene glycol) monolayer is patterned with aldehyde-terminated polyamidoamine dendrimers to allow the covalent immobilization of aminated oligonucleotide probes.
引用
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页码:315 / +
页数:6
相关论文
共 54 条
[1]   MANIPULATION OF THE WETTABILITY OF SURFACES ON THE 0.1-MICROMETER TO 1-MICROMETER SCALE THROUGH MICROMACHINING AND MOLECULAR SELF-ASSEMBLY [J].
ABBOTT, NL ;
FOLKERS, JP ;
WHITESIDES, GM .
SCIENCE, 1992, 257 (5075) :1380-1382
[2]   Next generation of protein microarray support materials:: Evaluation for protein and antibody microarray applications [J].
Angenendt, P ;
Glökler, J ;
Sobek, J ;
Lehrach, H ;
Cahill, DJ .
JOURNAL OF CHROMATOGRAPHY A, 2003, 1009 (1-2) :97-104
[3]  
Benters R, 2001, CHEMBIOCHEM, V2, P686, DOI 10.1002/1439-7633(20010903)2:9<686::AID-CBIC686>3.0.CO
[4]  
2-S
[5]   High-throughput cell analysis using multiplexed array technologies [J].
Beske, OE ;
Goldbard, S .
DRUG DISCOVERY TODAY, 2002, 7 (18) :S131-S135
[6]   Protein patterning [J].
Blawas, AS ;
Reichert, WM .
BIOMATERIALS, 1998, 19 (7-9) :595-609
[7]   Geometric control of cell life and death [J].
Chen, CS ;
Mrksich, M ;
Huang, S ;
Whitesides, GM ;
Ingber, DE .
SCIENCE, 1997, 276 (5317) :1425-1428
[8]   Neurobiology: At the root of brain cancer [J].
Clarke, MF .
NATURE, 2004, 432 (7015) :281-282
[9]   Loss of IGF2 imprinting:: A potential marker of colorectal cancer risk [J].
Cui, HM ;
Cruz-Correa, M ;
Giardiello, FM ;
Hutcheon, DF ;
Kafonek, DR ;
Brandenburg, S ;
Wu, YQ ;
He, XB ;
Powe, NR ;
Feinberg, AP .
SCIENCE, 2003, 299 (5613) :1753-1755
[10]   Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species [J].
Cui, Y ;
Wei, QQ ;
Park, HK ;
Lieber, CM .
SCIENCE, 2001, 293 (5533) :1289-1292