P(RNCH2CH2)3N-catalyzed synthesis of β-hydroxy nitriles

被引：82

作者：

Kisanga, P ^{[1
]}

McLeod, D ^{[1
]}

D'Sa, B ^{[1
]}

Verkade, J ^{[1
]}

机构：

[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 64卷 / 09期

关键词：

D O I：

10.1021/jo981858y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We herein report the successful synthesis of beta-hydroxy nitriles in very good to excellent yields from aldehydes and ketones in a simple reaction that is promoted by strong nonionic bases of the. title type. The reaction occurs in the presence of magnesium salts which activate the carbonyl group and stabilizes the enolate thus produced.

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页码：3090 / 3094

页数：5

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