Piperidinylpyrroles:: Design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands

被引：45

作者：

Haubmann, C ^{[1
]}

Hübner, H ^{[1
]}

Gmeiner, P ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Med Chem, Emil Fischer Ctr, D-91052 Erlangen, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(99)00540-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Piperidinylpyrroles of type 3 were synthesized through a modified Paal-Knorr reaction. For the introduction of pyrrole-substituents high yielding transformations including Sonogashira cross-coupling reactions were utilized. Employment of the reagent TosMIC gave access to the regioisomeric oxazolyl derivatives 7 and 11 which showed the highest dopamine D4 receptor binding of the series investigated. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3143 / 3146

页数：4

共 24 条

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