A poly(vinyl chloride) membrane electrode for the determination of the diuretic furosemide

被引：27

作者：

Dias, ILT

Neto, GD

Vendramini, DC

Sommer, C

Martins, JLS

Kubota, LT

机构：

[1] Univ Sao Francisco, UAACBS, Curso Farm, BR-12916900 Braganca Paulista, SP, Brazil

[2] Univ Sao Paulo, Fac Ciencias Farmaceut, Sao Paulo, Brazil

[3] Univ Estadual Campinas, Inst Quim, Campinas, SP, Brazil

来源：

ANALYTICAL LETTERS | 2004年 / 37卷 / 01期

关键词：

furosemide; poly(vinyl chloride) membrane electrode; ion-selective electrode; direct potentiometry; pharmaceutical analysis;

D O I：

10.1081/AL-120027772

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

New polymeric electrode responding to furosemide was constructed by incorporating the furosemide-aliquat ion pair complex into a poly(vinyl chloride) (PVC) membrane. The electrode exhibited a linear response over the concentration range 1.59 x 10(-4)-1.00 X 10(-2) mol L-1, a detection limit Of,. 19 X 10(-4) mol L-1 with E = - 245.6 - 58.9log[Fur]. The pH did not affect the response of the electrode within the range 7.0-10.0. Direct potentiometry was used to assay furosemide in pharmaceutical preparations. The results were compared with those obtained with spectrophotometric and chromatographic reference methods.

引用

页码：35 / 46

页数：12

共 44 条

[1] Salbutamol plastic membrane electrodes based on individual and mixed ion-exchangers of salbutamolium phosphotungstate and phosphomolybdate [J].