Harnessing the biosynthetic potential of modular polyketide synthases

被引:173
作者
Khosla, C [1 ]
机构
[1] STANFORD UNIV,DEPT CHEM & BIOCHEM,STANFORD,CA 94305
关键词
D O I
10.1021/cr960027u
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:2577 / 2590
页数:14
相关论文
共 46 条
[21]   ENGINEERED BIOSYNTHESIS OF A COMPLETE MACROLACTONE IN A HETEROLOGOUS HOST [J].
KAO, CM ;
KATZ, L ;
KHOSLA, C .
SCIENCE, 1994, 265 (5171) :509-512
[22]   Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase [J].
Kao, CM ;
Pieper, R ;
Cane, DE ;
Khosla, C .
BIOCHEMISTRY, 1996, 35 (38) :12363-12368
[23]   MANIPULATION OF MACROLIDE RING SIZE BY DIRECTED MUTAGENESIS OF A MODULAR POLYKETIDE SYNTHASE [J].
KAO, CM ;
LUO, GL ;
KATZ, L ;
CANE, DE ;
KHOSLA, C .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (35) :9105-9106
[24]   ENGINEERED BIOSYNTHESIS OF A TRIKETIDE LACTONE FROM AN INCOMPLETE MODULAR POLYKETIDE SYNTHASE [J].
KAO, CM ;
LUO, GL ;
KATZ, L ;
CANE, DE ;
KHOSLA, C .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (25) :11612-11613
[25]   Engineered biosynthesis of structurally diverse tetraketides by a trimodular polyketide synthase [J].
Kao, CM ;
Luo, GL ;
Katz, L ;
Cane, DE ;
Khosla, C .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (38) :9184-9185
[26]   Production of a novel polyketide through the construction of a hybrid polyketide synthase [J].
Kuhstoss, S ;
Huber, M ;
Turner, JR ;
Paschal, JW ;
Rao, RN .
GENE, 1996, 183 (1-2) :231-236
[27]   Erythromycin biosynthesis: Exploiting the catalytic versatility of the modular polyketide synthase [J].
Luo, GL ;
Pieper, R ;
Rosa, A ;
Khosla, C ;
Cane, DE .
BIOORGANIC & MEDICINAL CHEMISTRY, 1996, 4 (07) :995-999
[28]   COMPLEX ORGANIZATION OF THE STREPTOMYCES-AVERMITILIS GENES ENCODING THE AVERMECTIN POLYKETIDE SYNTHASE [J].
MACNEIL, DJ ;
OCCI, JL ;
GEWAIN, KM ;
MACNEIL, T ;
GIBBONS, PH ;
RUBY, CL ;
DANIS, SJ .
GENE, 1992, 115 (1-2) :119-125
[29]   STEREOSPECIFIC ACYL TRANSFERS ON THE ERYTHROMYCIN-PRODUCING POLYKETIDE SYNTHASE [J].
MARSDEN, AFA ;
CAFFREY, P ;
APARICIO, JF ;
LOUGHRAN, MS ;
STAUNTON, J ;
LEADLAY, PF .
SCIENCE, 1994, 263 (5145) :378-380
[30]   Gain-of-function mutagenesis of a modular polyketide synthase [J].
McDaniel, R ;
Kao, CM ;
Fu, H ;
Hevezi, P ;
Gustafsson, C ;
Betlach, M ;
Ashley, G ;
Cane, DE ;
Khosla, C .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (18) :4309-4310