Synthesis and biodistribution of 99mTc-carbonyltechnetium-labeled fatty acids

被引：30

作者：

Chu, TW ^{[1
]}

Zhang, Y ^{[1
]}

Liu, XQ ^{[1
]}

Wang, Y ^{[1
]}

Hu, SW ^{[1
]}

Wang, XY ^{[1
]}

机构：

[1] Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing 100871, Peoples R China

来源：

APPLIED RADIATION AND ISOTOPES | 2004年 / 60卷 / 06期

基金：

中国国家自然科学基金;

关键词：

fatty acid; myocardial metabolism imaging; carbonyl technetium; Tween-80;

D O I：

10.1016/j.apradiso.2004.02.006

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In order to image myocardial metabolism, Tc-99m(CO)(3)(+) complexes containing fatty acids were evaluated. At first, 11-(1-inudazolyl)-undecanoic acid (IUA) and 11-(2-(4-bromo-phenylazo)-1-imidazolyl)-undecanoic acid (BPIUA) were synthesized and the corresponding carbonyltechnetium-labeled complexes were prepared. However, unfortunately similar to those of other technetium-labeled fatty acid analogs, the biodistribution studies of Tc-99m(CO)(3)-IUA and Tc-99m(CO)(3)-BPIUA in mice demonstrated poor heart-to-blood ratios, thus these complexes cannot be used as heart-imaging reagents. In addition, Tween-80 can improve the biodistribution of the complexes for myocardial imaging. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：845 / 850

页数：6

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