Macrophage diversity in renal injury and repair

被引：627

作者：

Ricardo, Sharon D. ^{[1
,2
]}

van Goor, Harry ^{[3
,4
]}

Eddy, Allison A. ^{[5
,6
]}

机构：

[1] Monash Univ, MISCL, Clayton, Vic 3800, Australia

[2] Australian Stem Cell Ctr, Clayton, Vic 3800, Australia

[3] Univ Med Ctr Groningen, Dept Pathol & Med Biol, NL-9713 AV Groningen, Netherlands

[4] Univ Groningen, Groningen, Netherlands

[5] Univ Washington, Dept Pediat, Div Nephrol, Seattle, WA 98195 USA

[6] Seattle Childrens Res Inst, Seattle, WA USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2008年 / 118卷 / 11期

关键词：

D O I：

10.1172/JCI36150

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Monocyte-derived macrophages can determine the outcome of the immune response and whether this response contributes to tissue repair or mediates tissue destruction. In addition to their important role in immune-mediated renal disease and host defense, macrophages play a fundamental role in tissue remodeling during embryonic development, acquired kidney disease, and renal allograft responses. This review summarizes macrophage phenotype and function in the orchestration of kidney repair and replacement of specialized renal cells following injury. Recent advances in our understanding of macrophage heterogeneity in response to their microenvironment raise new and exciting therapeutic possibilities to attenuate or conceivably reverse progressive renal disease in the context of fibrosis. Furthermore, parallels with pathological processes in many other organs also exist.

引用

页码：3522 / 3530

页数：9

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