The paradoxical effects of vitamin D on type 1 mediated immunity

被引：103

作者：

Cantorna, Margherita T. ^{[1
]}

Yu, Sanhong ^{[1
]}

Bruce, Danny ^{[1
]}

机构：

[1] Penn State Univ, Ctr Mol Immunol & Infect Dis, Pathobiol & Immunol & Infect Dis Grad Program, Dept Vet & Biomed Sci, University Pk, PA 16802 USA

来源：

MOLECULAR ASPECTS OF MEDICINE | 2008年 / 29卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Vitamin D; Inflammatory bowel disease; Infectious immunity; Immune regulation;

D O I：

10.1016/j.mam.2008.04.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Low vitamin D status is associated with an increased risk of Th1 mediated autoimmune diseases like inflammatory bowel disease. 1,25(OH)(2)D-3 treatments have been shown to suppress Th1 mediated immunity and protect animals from experimental autoimmunity. Th1 mediated immunity is important for clearance of a number of different infectious diseases. For tuberculosis 1,25(OH)(2)D-3 treatment is associated with decreased Th1 mediated immunity but increased bactericidal activity. Systemic candidiasis is unaffected by 1,25(OH)(2)D-3 treatment. The seemingly paradoxical effects of 1,25(OH)(2)D-3 and vitamin D on Th1 mediated autoimmunity versus infectious immunity point to a broad array of vitamin D targets in the immune system. The interplay of these vitamin D targets and their impact on the host-immune response then dictate the outcome. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：369 / 375

页数：7

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