Environmental sensing through focal adhesions

被引：1932

作者：

Geiger, Benjamin ^{[1
]}

Spatz, Joachim P. ^{[2
,3
]}

Bershadsky, Alexander D. ^{[1
]}

机构：

[1] Weizmann Inst Sci, IL-76100 Rehovot, Israel

[2] Heidelberg Univ, D-69117 Heidelberg, Germany

[3] Max Planck Inst Met Res, D-70569 Stuttgart, Germany

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2009年 / 10卷 / 01期

基金：

美国国家卫生研究院; 以色列科学基金会;

关键词：

SELF-ASSEMBLED MONOLAYERS; VINCULIN-BINDING-SITE; CELL-MATRIX ADHESIONS; ACTIN STRESS FIBERS; INTEGRIN ACTIVATION; RHOA ACTIVITY; DIRECTIONAL CONTROL; ENDOTHELIAL-CELLS; NASCENT ADHESIONS; I/LWEQ MODULE;

D O I：

10.1038/nrm2593

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent progress in the design and application of artificial cellular microenvironments and nanoenvironments has revealed the extraordinary ability of cells to adjust their cytoskeletal organization, and hence their shape and motility, to minute changes in their immediate surroundings. Integrin-based adhesion complexes, which are tightly associated with the actin cytoskeleton, comprise the cellular machinery that recognizes not only the biochemical diversity of the extracellular neighbourhood, but also its physical and topographical characteristics, such as pliability, dimensionality and ligand spacing. Here, we discuss the mechanisms of such environmental sensing, based on the finely tuned crosstalk between the assembly of one type of integrin-based adhesion complex, namely focal adhesions, and the forces that are at work in the associated cytoskeletal network owing to actin polymerization and actomyosin contraction.

引用

页码：21 / 33

页数：13

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