Get on the exosome bus with ALIX

被引:166
作者
Hurley, James H. [1 ]
Odorizzi, Greg [2 ]
机构
[1] NIDDK, Mol Biol Lab, NIH, Bethesda, MD 20892 USA
[2] Univ Colorado, Dept Mol Cell & Dev Biol, Boulder, CO 80309 USA
关键词
UBIQUITINATION; MEMBRANE; VESICLES; PROTEIN;
D O I
10.1038/ncb2530
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Exosomes have a growing inventory of functions, but the mechanism of protein sorting into exosomes has been unclear. Now, a signal sequence first described in viral budding provides just such a cargo sorting mechanism, revealing closer-than-expected parallelism between exosome biogenesis and the ESCRT-dependent endolysdsomal pathway.
引用
收藏
页码:654 / 655
页数:2
相关论文
共 15 条
[1]   Syndecan-syntenin-ALIX regulates the biogenesis of exosomes [J].
Baietti, Maria Francesca ;
Zhang, Zhe ;
Mortier, Eva ;
Melchior, Aurelie ;
Degeest, Gisele ;
Geeraerts, Annelies ;
Ivarsson, Ylva ;
Depoortere, Fabienne ;
Coomans, Christien ;
Vermeiren, Elke ;
Zimmermann, Pascale ;
David, Guido .
NATURE CELL BIOLOGY, 2012, 14 (07) :677-685
[2]   Solution Structure of the ESCRT-I and -II Supercomplex: Implications for Membrane Budding and Scission [J].
Boura, Evzen ;
Rozycki, Bartosz ;
Chung, Hoi Sung ;
Herrick, Dawn Z. ;
Canagarajah, Bertram ;
Cafiso, David S. ;
Eaton, William A. ;
Hummer, Gerhard ;
Hurley, James H. .
STRUCTURE, 2012, 20 (05) :874-886
[3]   ALIX binds a YPX3L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting [J].
Dores, Michael R. ;
Chen, Buxin ;
Lin, Huilan ;
Soh, Unice J. K. ;
Paing, May M. ;
Montagne, William A. ;
Meerloo, Timo ;
Trejo, JoAnn .
JOURNAL OF CELL BIOLOGY, 2012, 197 (03) :407-419
[4]   Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding [J].
Fisher, Robert D. ;
Chung, Hyo-Young ;
Zhai, Qianting ;
Robinson, Howard ;
Sundquist, Wesley I. ;
Hill, Christopher P. .
CELL, 2007, 128 (05) :841-852
[5]   Cell biology of the ESCRT machinery [J].
Hanson, Phyllis I. ;
Shim, Soomin ;
Merrill, Samuel A. .
CURRENT OPINION IN CELL BIOLOGY, 2009, 21 (04) :568-574
[6]   Role of Ubiquitination in Endocytic Trafficking of G-Protein-Coupled Receptors [J].
Hislop, James N. ;
von Zastrow, Mark .
TRAFFIC, 2011, 12 (02) :137-148
[7]   The ESCRT complexes [J].
Hurley, James H. .
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2010, 45 (06) :463-487
[8]   Cargo ubiquitination is essential for multivesicular body intralumenal vesicle formation [J].
MacDonald, Chris ;
Buchkovich, Nicholas J. ;
Stringer, Daniel K. ;
Emr, Scott D. ;
Piper, Robert C. .
EMBO REPORTS, 2012, 13 (04) :331-338
[9]   ALIX catches HIV [J].
Martin-Serrano, Juan ;
Marsh, Mark .
CELL HOST & MICROBE, 2007, 1 (01) :5-7
[10]   An Alix fragment potently inhibits HIV-1 budding - Characterization of binding to retroviral YPXL late domains [J].
Munshi, Utpal M. ;
Kim, Jaewon ;
Nagashima, Kunio ;
Hurley, James H. ;
Freed, Eric O. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (06) :3847-3855